The EU H2020 project CO-FRESH brings together key actors from pilot agri-food value chains; actors’ associations (farmers, food producers, cooperatives, consumers); experts for technological (including digital) and non-technological (including social, organizational, and institutional) solutions; as well as experts in environmental and social science, economic sustainability, and in consumer acceptance. Starting from the state of the art in technological and non-technological approaches as well as current best practices and key success factors analysed in innovative value chains, CO-FRESH proposes to develop techniques, tools and insights for the re-design of agri-food value chains. Through collaborative and systemic approaches, the tools and formats will be applied in 7 pilot cases representing diverse fruit and vegetables agri-food value chains (including protein crops for food and feed) across Europe. CO-FRESH will use the Intervention Research approach, a research method examining the effects of an intervention on an outcome of interest, to study models of collective innovation action within and across organisations. The main objective of CO-FRESH is to (re)design and pilot innovative systemic approaches to agri-food value chains to scale up this innovation at European level. These innovative approaches will improve economic, social and environmental performance as well as efficiency of these value chains, through smart integration of technological, social, organisational, managerial and institutional innovations; all of which serve to make them more sustainable.