PestNu aims to revolutionize novel, digital and space-based technologies (DST) with agro-ecological and organic practices (AOP) in a systemic approach which can be applied in novel circular economy food production, such as aquaponics, as well as in hydroponic greenhouses and open-field vegetable cultivation for reducing the dependence on hazardous pesticides; reducing the losses of nutrients from fertilisers, towards zero pollution of water, soil and air and ultimately fertiliser use.