PEFMED is the largest trasnational initiative ever carried out in the Mediterranean space to encourage a pool of companies from 9 Mediterranean agrofood regional systems belonging to 6 Mediterranean Countries (Italy, Spain, France, Portugal, Greece and Slovenia) to green the own production according to the new EU Product Environmental Footprint method (PEF), the unique next-generation method to assess the environmental performances of a product during its lifecycle. Between 2016-2019, hundreds of companies, LCA specialists, business analysts and national agrofood associations cooperate to foster targeted systemic ecoinnovation interventions within industrial clusters, raise the market value of PEF-compliant productions and galvanize the regional Smart Specialization Strategies (RIS3) goals related to innovation in agrofood and industrial production.